ELABORATELY ENGINEERING OF A DUAL-DRUG CO-ASSEMBLED NANOMEDICINE FOR BOOSTING IMMUNOGENIC CELL DEATH AND ENHANCING TRIPLE NEGATIVE BREAST CANCER TREATMENT

Pure drug-assembled nanosystem provides a facile and promising solution for simple manufacturing of nanodrugs, whereas a lack of understanding of the underlying assembly mechanism rosy teacup dogwood and the inefficient and uncontrollable drug release still limits the development and application of this technology.Here, a simple and practical nanoa

BACKGROUND: Sedentary behaviour and an insufficient level of physical activity in children are the key factors leading to physically inactive behaviour in adulthood associated with the growing prevalence of mass non-communicable diseases in the population of the Czech Republic.OBJECTIVES: The aim of this study was to analyze sedentary lifestyle, fo

Bacteria express a plethora of efflux pumps that can transport structurally varied molecules, including antimicrobial agents and antibiotics, out of cells.Thus, efflux pump systems participate in lowering intracellular concentrations of antibiotics, which allows phenotypic multidrug-resistant (MDR) bacteria to survive effectively amid higher concen

Tramadol is a synthetic opioid that is widely used as an analgesic for alleviating pain of moderate to medium intensity.With potency estimated to be about one-tenth that of morphine, tramadol is considered as relatively safe with regard to poisonings or dependency.Yet there are beer button down shirts for men increasing reports of widespread non-me

The role of surveying in the construction of less demanding construction works was defined in more detail with the adoption of the new legislation.The surveyor is present in all stages, i.e.before, during and after the construction of a building, which is actually from the time the land is purchased and until the operating permit is obtained and th